Early use of antiviral medication may help prevent lung failure in children with the flu. http://t.co/5VywEgjX
Children hospitalized for the flu are much less likely to require breathing support from a mechanical ventilator if they receive antiviral drugs like oseltamivir (Tamiflu®) as soon as possible after admission, according to researchers at Boston Children's Hospital. The findings, based on an analysis of pediatric hospital data nationwide, suggest that early use of such drugs may help prevent lung failure in children with severe flu infections, and argue for their early use in a pediatric hospital setting during flu season. A team of investigators led by Boston Children's Carl Eriksson, MD, MPH (now at Oregon Health and Science University), Adrienne Randolph, MD, MSc, and Timothy Uyeki, MD, MPH, from the U.S. Centers for Disease Control and Prevention (CDC) reported these results November 5 in the journal Pediatric Critical Care Medicine. The 2009 H1N1 influenza pandemic led to a significant increase in the numbers of children hospitalized for the flu or flu-related complications. "About 70 percent of children hospitalized for the flu during the 2009 pandemic were prescribed antiviral medication, mostly Tamiflu," Randolph explained, "whereas only 19 percent of such children received antiviral treatment during the three previous flu seasons." When the researchers looked at the risk factors for mechanical ventilation for both seasonal and pandemic flu, one thing stood out: children prescribed Tamiflu shortly after admission for the flu were much less likely than children who did not receive the antiviral to require a ventilator at day 3 or later of their hospital stay. The association held for children hospitalized for seasonal influenza and for those admitted during the 2009 pandemic. The results suggest that because these children received early antiviral treatment in the hospital, their flu infection was less likely to worsen to the point that their lungs started to fail.
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